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Interaction of testosterone-based compounds with dodecyl sulphate monolayers at the air water interface Physical Chemistry Chemical Physics RSC Publishing

Interaction of testosterone-based compounds with dodecyl sulphate monolayers at the air water interface Physical Chemistry Chemical Physics RSC Publishing

New users can often expect to see significant gains in muscle mass and strength on cycle. For more experienced users the effects can be less exaggerated, however, still substantial. Testosterone propionate is often used by athletes who require shorter but more explosive steroid cycles. It is proven time and time again as a reliable and effective muscle builder. Whilst starting protocols may look similar to each other, these are then adapted to the patient, their blood work and their lifestyle. It is, however, difficult to predict the effect that HCG will have on a man’s production.

  • We should be responsive to both qualitative and quantitative research, alongside clinical experience.
  • For example, buccal (oral) administered Testosterone generally causes a peak of Testosterone levels within hours of initial administration, and reaches steady state within 24 hours 4.
  • Most men want a balance between the most convenient treatment protocol with the best results possible.
  • High levels of testosterone in the body can often result in more androgenic based side effects including; oily skin, acne, increase in body and facial hair growth.
  • Achieving stable levels is all about tailoring injection dose and frequency according to need, and titrating that level up or down according to both qualitative and quantitve markers.
  • Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve.

Once clinical practice has returned to normal after the COVID-19 pandemic, we plan to engage in a clinical trial to demonstrate the effectiveness of microdosing. In clinical practice, the difference that daily injections of Testosterone Cypionate (or Enanthate) have had on stability has also been quite marked. Using the most effective injection frequency with the lowest viable dose, to achieve the most optimal patient outcome. This includes looking at patient symptoms, discussion of how the patient feels, biochemical assays/profiles, body composition changes, energy, activity performance and mental wellbeing.

Where Do You Inject Test Prop?

It is not best for men with lower body fat levels but may be worth considering if you are rotating injection sites. 125mg administered every five days via deep intramuscular (IM) injection. It is important to note that a deep intramuscular injection will generally lead to a faster rate of absorption, but also a subsequent quicker decline in Testosterone levels too. How much Testosterone you may release in response to a bolus dose of Testosterone Undecanoate versus another male individual, will vary based on a number of factors.

  • Testosterone propionate injections can take up to 6 weeks to start taking effect.
  • We have discussed the evolution of our clinical practice in ‘Gold Standard TRT’.
  • Such a dosing protocol may over time lead to excess oestradiol due to large peaks and troughs.
  • I hope it’s now clear why I use Testosterone Cypionate (or Enanthate if prescribed via the NHS) as my GOLD STANDARD TRT at The Men’s Health Clinic.
  • This is also true of Testosterone and its different compounds, from different ester injectable drugs, to gels and more.

However, we believe obesity and lack of physical activity are the largest contributory factors resulting in a decline in Testosterone levels, discussed in depth in ‘Me & My Fat – The Role of Fat on Your Hormonal Health‘. The aromatase enzyme, which converts Testosterone to Oestradiol is located in both peripheral and visceral adiposity. This is the biggest single challenge for both patient and clinician in attaining a healthy Testosterone to Oestradiol ratio for optimal well-being. From analysing and reflecting on the above data, it should now be clear why we consider gold standard TRT to be DAILY Testosterone and HCG injections. The goal of TRT is to provide the necessary foundations for achieving hormonal balance and attaining a semblance of normality in one’s life. Our Patient Zero is still with us today and has agreed to let us use his data to demonstrate on both an anecdotal and case study level, how effective microdosing has been for him.

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There isn’t one particular protocol that is best for everyone, because everyone has different physiologies, phobias and commitments. Some evidence suggests they require a lower dose to achieve the same level of testosterone as Intramuscular. It is safer as there is less chance of injecting testosterone oil into a blood vessel. The customer shall indemnify VWR against any claims made against VWR by the customer’s employees, contractors or agents.

  • Therefore, to titrate your optimal dose and frequency, it is sensible to use only one variable.
  • It is proven time and time again as a reliable and effective muscle builder.
  • As we can see, more stable levels are reached with smaller differences between the peaks and troughs.
  • If you are suffering from low testosterone and the side effects that come along with it, you are probably pretty eager to see the results of testosterone propionate injection treatments.
  • Additionally, testosterone injections carry the benefit of being very convenient and easy to administer.

Balance My Hormones will work with you to find the optimal dose and help ensure you are getting the correct dose that works best with your body. Every milligram of Testosterone Propionate used results in more actual Testosterone being utilized by the body compared to a longer ester such as Testosterone Enanthate. It isreported that 100mg of Testosterone Propionate is about 125% stronger than 100mg of Testosterone Enanthate. It’s essential to monitor these side effects and consult a healthcare professional if they become severe.

As already mentioned, there is individual variation in drug metabolism of the different esters and there is no defined optimal testosterone level, so you cannot apply a standard fixed dose and frequency of injection to achieve stability. Therefore, to titrate your optimal dose and frequency, it is sensible to use only one variable. It also makes sense that the action of this variable should be predictable, something that has been demonstrated with testosterone enanthate; oestradiol and DHT levels exhibit saturable increases with increased dose(9). It comes as no secret that both subcutaneous and shallow intramuscular injections are the most effective method of delivering a consistent dose of testosterone to the bloodstream.


More specifically ‘Propionate’ is Propionic acid, but once bound to Testosterone it can be referred to as an ester bond. Esterified anabolic steroids tend to be more fat-soluble, thus allowing Testosterone to release slowly from the injection site. Testosterone propionate is a great choice of steroid for anyone looking to run shorter cycles or cutting cycles. In rare cases or when users have been on cycle for prolonged periods, people can be shut down permanently or suffer from low testosterone levels for many years.

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Gold standard TRT extends even further than this, the aim is to also optimise function by giving men an appropriate dose of Testosterone and HCG for their genetics, physiological requirements, and subsequent utilisation. This can only be done through careful titration, its certainly a case of “slow and steady wins the race”. Administration of a medication forces a physiological reaction, even if that medication is “body-identical”, a new buzz term in the healthcare sector. This means it has a subsequent knock on effect on all the parameters that Testosterone, Oestradiol, and DHT influence. It’s role is discussed in detail in ‘TRT, SHBG & Health – Facts, Questions and Evolution‘.

The 24-hour diurnal rhythm of natural testosterone production is demonstrated in the graph below. The peaks and troughs are clearly significant, and it would take considerable time for the decanoate ester to achieve stable levels. It’s also known that this causes supraphysiological Testosterone levels, which subsequently decline very quickly and can lead to polycythaemia, a feeling of “roller-coaster” emotions, and other issues 7.

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